As always, this question can be answered in two ways, at least for me.
Which show would I be more likely to take a great deal of money away from? Wheel, no question. The contestants they're bringing in are morons, and they have such an acute case of Mo' Money Syndrome over there that I'd have to actually make a concerted effort to walk away with less than ten grand.
So if I could only be on one show, that's what I'd do to maximize my profits.
Now, if money isn't an issue, and I wanted to go on the show to play the game? $25,000 Pyramid, please, no question. The Jack Narz Concentration would run second, and any incarnation of Sale would be third.